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4 edition of Nucleophilic aromatic substitution of hydrogen found in the catalog.

Nucleophilic aromatic substitution of hydrogen

O. N. Chupakhin

Nucleophilic aromatic substitution of hydrogen

by O. N. Chupakhin

  • 161 Want to read
  • 25 Currently reading

Published by Academic Press in San Diego .
Written in English

    Subjects:
  • Substitution reactions.,
  • Aromatic compounds.

  • Edition Notes

    Includes bibliographical references (p. 287-355) and index.

    StatementOleg N. Chupakhin, Valery N. Charushin, Henk C. van der Plas.
    ContributionsCharushin, Valery N., Plas, H. C. van der.
    Classifications
    LC ClassificationsQD281.S67 C48 1994
    The Physical Object
    Paginationx, 367 p. :
    Number of Pages367
    ID Numbers
    Open LibraryOL1096233M
    ISBN 100121746402
    LC Control Number94020812

    The cationic metallabenzenes [Ir(C5H4{SMe-1})(κ2-S2CNEt2)(PPh3)2]PF6 (1) and [Os(C5H4{SMe-1})(CO)2(PPh3)2][CF3SO3] (2) undergo regioselective nucleophilic aromatic substitution of hydrogen at the metallabenzene ring position γ to the metal in a two-step process that first involves treatment with appropriate nucleophiles and then by: Electrophilic aromatic substitution is an organic reaction in which an atom that is attached to an aromatic system (usually hydrogen) is replaced by an electrophile.

    Organic Chemistry Notes. This note covers the following topics: structure determines properties, hydrocarbon frameworks alkanes, conformations of alkanes and cyclo alkanes, alcohols and alkyl halides, structure and preparation of alkenes elimination reactions, reactions of alkenes addition reactions, stereochemistry, nucleophilic substitution, alkynes, conjugation in alkadienes and . Abstract. Analysis of many variants of nucleophilic aromatic substitution of hydrogen proceeding according to an addition—elimination pattern reveals that this is the major reaction pathway, whereas nucleophilic replacement of halogen or another nucleofugal group is the secondary process, i.e., this respect electrophilic and nucleophilic aromatic substitution Cited by:

    Books. Study. Textbook Solutions Expert Q&A Question: Which Of The Following Is Most Reactive Toward Nucleophilic Aromatic Substitution? I II III IV V. This problem has been solved! Previous question Next question Transcribed Image Text from this Question. Which of the following is most reactive toward nucleophilic aromatic substitution. Mechanism of the Vicarious Nucleophilic Substitution. It was well known that polynitroarenes form stable adducts with various nucleophiles (Meisenheimer complexes) and that bond formation to carbon atoms bearing hydrogen is faster than to .


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Nucleophilic aromatic substitution of hydrogen by O. N. Chupakhin Download PDF EPUB FB2

Nucleophilic aromatic substitution in carbo- and heteroaromatic systems is a subject of considerable interest to chemists. This book uniquely addresses the systematic analysis of a vast range of nucleophilic substitutions of aromatic : Hardcover.

Nucleophilic aromatic substitution in carbo- and heteroaromatic systems is a subject of considerable interest to chemists. This book uniquely addresses the systematic analysis of a vast range of nucleophilic substitutions of aromatic hydrogen. His research interest is in chemistry, mainly in the field of nucleophilic substitution and ring transformations.

The results of his scientific results are set down in nearly research papers, 20 review articles, and in two monographs, and a book (together with O. Chupakhin and V. Charushin), Nucleophilic Substitution of Aromatic by: Nucleophilic aromatic substitution of hydrogen.

San Diego: Academic Press, © (OCoLC) Material Type: Internet resource: Document Type: Book, Internet Resource: All Authors / Contributors: O N Chupakhin; Valery N Charushin; H C van der Plas. This book provides a comprehensive overview of nucleophilic aromatic substitutions, focusing on the mechanistic and synthetic features that govern these reactions.

The first chapter presents a detailed mechanistic analysis of the Nucleophilic aromatic substitution of hydrogen book determining the feasibility of SNAr substitutions. Nucleophilic substitution of hydrogen in electron‐deficient arenes, particularly nitroarenes, is an efficient and versatile tool for introduction of a variety of C, N, O, and other substituents into aromatic : Mieczysław Mąkosza.

This book provides a comprehensive overview of nucleophilic aromatic substitutions, focusing on the mechanistic and synthetic features that govern these reactions.

The first chapter presents a detailed mechanistic analysis of the factors determining the feasibility of SNAr substitutions, providing decisive information to predict regioselectivity of many reactions and to define the.

How to cite this article: Mąkosza M. Nucleophilic Aromatic Substitution, General Corrected Mechanism And Versatile Synthetic Tool. Organic & Medicinal Chem IJ. ; 2(1): ArH of hydrogen can proceed in the same molecule of a halo nitrobenzene they can be considered as complementary Size: KB.

Buy Nucleophilic Aromatic Substitution of Hydrogen by Chupakhin, Oleg N., etc., Charushin, Valery N., van der Plas, Henk C. (ISBN: ) from Amazon's Book Store. Everyday low prices and free delivery on eligible : Oleg N. Chupakhin, etc., Valery N.

Charushin. Nucleophilic aromatic substitution. A nucleophilic aromatic substitution is a substitution reaction in organic chemistry in which the nucleophile displaces a good leaving group, such as a halide, on an aromatic ring.

Nucleophilic aromatic substitution of hydrogen has been elucidating predominantly as C–H functionalization of π-deficient aromatic and heteroaromatic compounds.6, 7, 8, 9, 10, 11, 12, 13, 14 However, the scope of the S N H reactions is not Cited by: Cathodically activated nucleophilic aromatic substitution of hydrogen (S N Ar H) is reported for the first time; the 1,3,5-trinitrobenzene radical anion reacts with the nucleophile N-methylformamide leading to high yields of the σ H-complex radical anion; this intermediate can be easily oxidised electrochemically by means of a three-electron mechanism giving rise to the nucleophilic aromatic Cited by: 8.

Nucleophilic aromatic substitution in carbo- and heteroaromatic systems is a subject of considerable interest to chemists. This book uniquely addresses the systematic analysis of a vast range of nucleophilic substitutions of aromatic hydrogen.*.

Nucleophilic substitution of hydrogen in electron-deficient arenes, particularly nitroarenes, is an efficient and versatile tool for introduction of a variety of C, N, O, and other substituents. Modern Nucleophilic Aromatic Substitution. Francois Terrier.

ISBN: pages. August Description. This book provides a comprehensive overview of nucleophilic aromatic substitutions, focusing on the mechanistic. Basic Principles of Organic Chemistry. This book explains the following topics: Structural Organic Chemistry, The Shapes Of Molecules, Functional Groups, Organic Nomenclature, Alkanes, Bonding In Organic Molecules- Atomic-orbital Models, Nucleophilic Substitution And Elimination Reactions, Separation and Purification- Identification Of Organic.

The nucleophilic aromatic substitution of hydrogen is one of the most rapidly developing and promising areas of research in organic synthesis. 1 – 3 The reactions have a great synthetic potential due to the fundamental property of C–H bonds in -deficient arenes and hetarenes, namely, high susceptibility to nucleophilic attack resulting, under certain conditions in the Cited by: Nucleophilic Aromatic Substitution for Hydrogen Reduction in chemical waste generation elimination of 74% of organic waste 99% of inorganic waste Eliminates use of chlorine Reduction in waste water more than 97% savings Eliminates use of xylene a SARA chemical Improves process safety lower reaction temperatures.

Nucleophilic aromatic substitution of hydrogen as a tool for the synthesis of indole and quinoline derivatives. Makosza, K. Wojciechowski, Heterocycles,54, Key Words.

electrophilic aromatic substitution (second step) The gain in stabilization attendant on regeneration of the aromatic ring is sufficiently advantageous that this, rather than combination of the cation with \(\ce{Y}^\ominus\), normally is the favored course of reaction.

Herein lies the difference between aromatic substitution and alkene addition. Vicarious nucleophilic substitution. In organic chemistry, the vicarious nucleophilic substitution is a special type of nucleophilic aromatic substitution in which a nucleophile replaces a hydrogen atom on the aromatic ring and not leaving groups such as halogen substituents which are ordinarily encountered in S NAr.Direct formation of aromatic C–N bonds.

Regioselective amination of m-dinitrobenzene via fluoride promoted nucleophilic aromatic photosubstitution for hydrogen. Tetrahedron Letters41 (2), DOI: /S(99)Cited by:   Purchase Organic Chemistry - 1st Edition. Print Book & E-Book. ISBNBook Edition: 1.